ChemInform Abstract: Aselacins, Novel Compounds that Inhibit Binding of Endothelin to Its Receptor. Part 2. Isolation and Elucidation of Structures.

Abstract

Aselacins, Novel Compounds that Inhibit Binding of Endothelin to Its Receptor. Part 2. Isolation and Elucidation of Structures.-From two related Acremonium species of fungi grown in stationary culture the cyclic title pentapeptolides (I) are isolated. These aselacins A, B and C differ in the functionalization of the fatty acid part. -(HOCHLOWSKI, J. E.; HILL, P.; WHITTERN, D. N.; SCHERR, M. H.; RASMUSSEN, R. R.; DORWIN, S. A.; MCALPINE, J. B.; J. Antibiot. 47 (1994) 5, 528-535; Pharm. Prod. Res. Dev., Abbott Lab., Abbott Park, IL 60064, USA; EN)