ChemInform Abstract: Arteminolide, an Inhibitor of Farnesyl Transferase from Artemisia sylvatica

Abstract

Arteminolide, an Inhibitor of Farnesyl Transferase from Artemisia sylvatica -[isolation and structure elucidation]. -(LEE, S.-H.; KIM, M.-J.; BOK, S. H.; LEE, H.; KWON, B.-M.; SHIN, J.; SEO, Y.; J.

Long fascicular tissue fragments in desmoid fibromatosis by fine needle aspiration: A new cytologic feature

“…2), can inhibit the Ras signaling pathway in H‐RasV12‐transformed Rat2 cells. APE was isolated from the Artemisia sylvatica ,17 and AP‐Rd was prepared by reduction of the α‐methylene‐γ‐lactone group of APE. Both APE and AP‐Rd blocked H‐Ras farnesylation, but APE has a sequiterpene lactone with the α‐methylene‐γ‐lactone, which exhibits a wide range of biological activities23 and has cytotoxicity in normal cells.…”

“…Arteminolide‐Rd (AP‐Rd) was prepared by reduction of the α‐methylene‐γ‐lactone group of APE 17. SCH66336 and LB42908 were synthesized by reported methods 19.…”

“…Being used, the inhibitors having quite different structures are optimized through the chemical modification. Arteminolide‐Rd (AP‐Rd) is prepared by reduction of the α‐methylene‐γ‐lactone group of arteminolide E (APE), which was isolated from the aerial parts of Artemisia sylvatica 17. APE is a sesquiterepne lactone.…”

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

“…Lee et al 22 isolated a compound from the leaves of Artemisia sylvatica Maxim in 1998. It was determined to be arteminolide (65) by NMR, IR, HREIMS, NOESY spectrum, and mass spectral data.…”