ChemInform Abstract: Antitumor Imidazotetrazines. Part 36. Conversion of 5‐Aminoimidazole‐4‐carboxamide to Imidazo[5,1‐d][1,2,3,5]tetrazin‐4(3H)‐ones and Imidazo[1,5‐a][1,3,5]triazin‐4(3H)‐ones Related in Structure to the Antitumor Agents Temozolomide and Mitozolomide.

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Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas

“…Acid 6 was transformed into chloroanhydride 7 by the treatment with PCl 5 according to [23] that is a modified method reported in [24]. Previously, 3,3,3-trifluoroisocyanate 8 was synthesized from 3,3,3-trifluoroethylamine and phosgene [25–27], by thermal degradation of N -diphenyl- N '-(3,3,3-trifluoroethyl) urea [28, 29]. It was also synthesized using a Curtius reaction of chloroanhydride 7 and sodium azide [30], but isocyanate 8 was not isolated.…”