ChemInform Abstract: ANIONENAKTIVIERUNG 1. MITT. ANIONENAKTIVIERUNG DURCH MAKROCYCLISCHE POLYAETHER UND IHR EINFLUSS AUF NUCLEOPHILE SUBSTITUTIONSREAKTIONEN

Abstract

Acetobromglucose (I) wird mit Silbernitrat (II) und Alkoholen (III) umgesetzt und hierbei werden Mischungen aus den Glucosiden (IV) und den Salpetersäureestern (V) erhalten.

Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century

“…To improve the glycoside synthesis, several soluble silver salts were introduced as promoters for the activation of glycosyl bromides. These salts include silver acetate, , which led to the predominant 1- O -acetylation, silver nitrate first studied by Koenigs and Knorr, and in a greater detail investigated by Knöchel et al , Several other soluble silver salts were explored including perchlorate, , tetrafluoroborate, , hexafluorophosphate, and trifluoromethanesulfonate (triflate) . While being efficient activators, these silver salts required multiple equivalents of the acid scavenger to be added in these reactions.…”