ChemInform Abstract: Analytical Application of the Reactions of 2,10‐Disubstituted Phenothiazines with Organic Substances

Tarasiewicz, M.; Wołyniec, Elżbieta; Puzanovska‐Tarasiewicz, H.

doi:10.1002/chin.199831290

Cited by 5 publications

(9 citation statements)

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“…Psychotropic substances, e.g. phenothiazines, dibenzocycloheptadienes and thioxantenes react with organic substances, which occur as anions in aqueous solutions forming colored ion-association binary compounds[ 20 ]. These compounds are insoluble into organic solvents, e.g.…”

Section: Binary and Ternary Complexes Of Psychotropic Drugsmentioning

confidence: 99%

Spectroscopic and electrochemical analysis of psychotropic drugs

Puzanowska-Tarasiewicz

Misiuk

Mielech-Łukasiewicz

et al. 2009

Indian J Pharm Sci

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Psychotropic drugs are an important family of compounds from a medical point of view. Their application in therapy requires methods for the determination in pharmaceutical dosage forms and body fluids. Several methods for their analysis have been reported in the literature. Among the methods, spectrophotometric and electrochemical are very useful for the determination of the drugs. Some of the spectrophotometric methods are based on the formation of the binary and ternary compounds with complexes of metals. The formed compounds are sparingly soluble in water, but quantitatively extracted from aqueous phase into organic solvents and the extracts are intensely colored and stable for a few days. These complexes have been employed in pharmaceutical analysis. The electrochemical procedures are very useful in determination of the psychotropic substances in pharmaceutical preparations.

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Section: Binary and Ternary Complexes Of Psychotropic Drugsmentioning

confidence: 99%

Spectroscopic and electrochemical analysis of psychotropic drugs

Puzanowska-Tarasiewicz

Misiuk

Mielech-Łukasiewicz

et al. 2009

Indian J Pharm Sci

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“…Also, this drug was proposed as a chelating agent for the determination of some metal ions like Cr +6 [21], Tl 3+ [22], Fe 3+ [23] ions. In general, one can refer to the analytical applications of the reactions of phenothiazine derivatives with some metal ions through access to the best article published an article in 1999 [24].…”

Section: Introductionmentioning

confidence: 99%

Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

Khammas¹

2015

SJAC

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A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer's law obeyed in the concentration range of 2-80 µg mL -1 (r = 0.9999) for the determination of TFPH and 0.5-10 µg mL -1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 µg mL -1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.

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“…Among the methods, UV spectrophotometry and conventional high performance liquid chromatography are most often used [8][9][10][11]. Voltammetry [12][13][14], spectrophotometry [15][16][17][18][19], and chemiluminescence methods have been reported for the determination of thioridazine hydrochloride [20]. Supercritical fluid chromatography [21] and LC combined with other techniques were also reported for determination of thioridazine hydrochloride [22,23] and their main metabolites or derivatives.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Thioridazine Hydrochloride in Tablets and Biological Fluids by Ion-Pair and Oxidation Reactions

El‐Didamony

Hafeez²

2012

Spectroscopy: An International Journal

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Two simple, sensitive and selective spectrophotometric methods have been described for the determination of the psychoactive drug, thioridazine HCl in tablets and in biological fluids. The first method is based on the oxidation of thioridazine HCl with measured excess of KMnO4under acidic conditions followed by the determination of unreacted oxidant using indigo carmine and methyl orange. The second method is based on the formation of ion-pair complexes with the acidic sulphophthalein dyes such as bromocresol green and bromocresol purple at pH 1.8 of KCl-HCl buffer. The formed complexes were extracted into methylene chloride and their absorbance was measured at 412 nm. Optimizations of the different experimental conditions are described for both methods. The proposed methods were successfully applied for determination of the drug in tablets and biological fluids with good accuracy and precision. Statistical comparison of the results with those obtained by an official method showed good agreement and indicated no significant difference in accuracy and precision.

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ChemInform Abstract: Analytical Application of the Reactions of 2,10‐Disubstituted Phenothiazines with Organic Substances

Cited by 5 publications

References 0 publications

Spectroscopic and electrochemical analysis of psychotropic drugs

Spectroscopic and electrochemical analysis of psychotropic drugs

Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

Spectrophotometric Determination of Thioridazine Hydrochloride in Tablets and Biological Fluids by Ion-Pair and Oxidation Reactions

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