ChemInform Abstract: ANALOGS OF AMINOGLUTETHIMIDE: SELECTIVE INHIBITION OF AROMATASE

Foster, A.; Jarman, Michael; Leung, C.-S.; Rowlands, Martin; Taylor, Graeme K.; Plevey, R. G.; Sampson, Paul

doi:10.1002/chin.198524229

Cited by 3 publications

(1 citation statement)

References 1 publication

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“…Recently, several new aromatase inhibitors have been developed. RG (7) is under Phase I clinical trials, and 40HA (8) has just been licensed in the United Kingdom and New Zealand [17,18]. HPLC is the most commonly used analytical method available for quantification of these drugs in biological fluids, with structural confirmation being carried out either by off-line [19] or on-line TSP/MS [20][21][22].…”

Section: Aromatase Inhibitorsmentioning

confidence: 99%

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Poon

Bisset

Mistry

1993

J. Am. Soc. Mass Spectrom.

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In this study, several anticancer drugs and their analogues consisting of organic and organometallic compounds were analyzed by electrospray ionization mass spectrometry (ESI/MS) using a quadrupole mass spectrometer. Protonated molecular ions [M+H](+) were observed for all of the compounds studied, and in the case of the two steroid sulfates, deprotonated molecular ions [M-H](-) were obtained. Tandem mass spectrometry was performed on these quasimolecular ions, and the product ions formed provided useful fragmentation patterns that were characteristic for the compounds. This study provides evidence that ESI/MS is a sensitive technique for structure confirmation and identification of small organic and organometallic molecules.

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Section: Aromatase Inhibitorsmentioning

confidence: 99%

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Poon

Bisset

Mistry

1993

J. Am. Soc. Mass Spectrom.

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Pyridoglutethimide [3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione], an analogue of aminoglutethimide

Seago

Goss

Griggs

et al. 1986

Biochemical Pharmacology

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Characterisation of metabolites of 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione, a potential breast cancer drug

Poon

McCague

Griggs

et al. 1991

Journal of Chromatography B: Biomedical Sciences and Applicatio

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ChemInform Abstract: ANALOGS OF AMINOGLUTETHIMIDE: SELECTIVE INHIBITION OF AROMATASE

Abstract: Ausgehend von den Pyridinen (I) und (VIII) erhält man gemäß Formelschema die Verbindungen (V)‐(VII) sowie (XV), die auf Aromatase‐ und Desmolase‐inhibierende Wirkun untersucht werden.

Cited by 3 publications

References 1 publication

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Pyridoglutethimide [3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione], an analogue of aminoglutethimide

Characterisation of metabolites of 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione, a potential breast cancer drug

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