ChemInform Abstract: An Improved Procedure for the Preparation of the Dess‐Martin Periodinane.

Abstract

An Improved Procedure for the Preparation of the Dess-Martin Periodinane.-Treatment of 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (I) with acetic anhydride (II) in the presence of catalytic amounts of ptoluenesulfonic acid gives the title compound (III) in high yield and reproducible quality. -(IRELAND, R. E.; LIU, L.; J.

Progress Towards the Total Synthesis of Hydroxybrazilin

“…With these driving forces, the first synthesis of quinine was reported in 1944 by Woodward 8 , however the synthesis is suspected to be for d-quinotoxine, which had previously been shown to be easily converted to quinine by Rabe 9 .…”

“…Returning to our synthesis, we then attempted to again follow Kortokov's plan, and oxidize both the primary and secondary alcohols with DMP. The DMP was prepared utilizing oxone to make precursor IBX, which was then acetylated with acetic anhydride to yield DMP, as opposed to being acquired commercially (Scheme 2-14) 9 .…”