“…Its products (Mannich bases) are of considerable importance in industry, natural products, chemistry, and pharmacy (Azend et al , 1998 ). A large number of studies on the Mannich-type reactions have been reported (Gu et al , 2008 ;Uraguchi et al , 2008 ;Bayrak et al , 2009 ;Candeias et al , 2009 ;Hong et al , 2009 ;Odedra and Seeberger , 2009 ) with many methods utilizing Lewis acids (Ollevier and Nadeau , 2007 ;Stas and Tehrani , 2007 ;Wang et al , 2007b ;Wu et al , 2007b ;Ramalingam and Kumar , 2008 ;Sanjeeva and Purnachandra , 2008 ;Chen et al , 2009 ), Bronsted acids (Guo et al, 2007;Rueping et al, 2007;Yamanaka et al, 2007), solid acids (Bigdeli et al , 2007 ;Li et al , 2007 ;Wang et al , 2007a,c ;Reddy et al , 2008 ), bases (Chandler et al , 2009 ;Wu et al , 2009 ), metal complexes (Wu et al , 2007a ;Wieland et al , 2009 ), ionic liquids (Dong et al , 2007 ;Fang et al , 2009 ), inorganic salts (Aryanasab and Saidi , 2008 ;Kidwai et al , 2008 ), and organic compounds (Verkade et al , 2008 ;Kano et al , 2009 ) as catalysts and many volatile organic solvents, some of which are hazardous for the environment. There are few reports on the use of heteroarylamines as substrates in the Mannich-type reactions (Shaabani et al , 2007 ;Hao et al , 2009 ).…”