Abstract:AnEfficient Asymmetric Synthesis of (3S)-3-Amino-1-(4cyanophenyl)-2-oxopyrrolidine Hydrochloride Salt.-Coupling of bromide (II) with nitrile (III) and subsequent cyclization gives the lactam ring of the title compound. Displacement of the bromide in intermediate (IV) by treatment with excess NH 4 OH and work-up of the racemic amine with (R)-mandelic acid (V) leads to isolation of the racemic (R)-mandelic acid salt (VI). The optically pure title compound is then obtained through the dynamic resolution of amine … Show more
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