ChemInform Abstract: An Alternative Synthesis of the Enantiomerically Pure Competitive NMDA Antagonists SDZ 220‐581 and SDZ EAB 515.

Abstract

An Alternative Synthesis of the Enantiomerically Pure Competitive NMDA Antagonists SDZ 220-581 and SDZ EAB 515.-The title compounds are synthesized starting from tyrosine derivative (I) as alternative to a method starting from a chiral glycine derivative. -(MUELLER, W.; BAENZIGER, M.; KIPFER, P.; Helv. Chim. Acta 81 (1998) 4, 729-733; Novartis Pharma AG, CH-4002 Basel, Switz.; EN)