ChemInform Abstract: Aminoalkylation of Electron‐Rich Aromatic Compounds Using Preformed Iminium Salts Derived from Aldehydes Other than Formaldehyde.

Abstract

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Synthesis of enantiopure 2‐(aminoalkyl)phenol derivatives and their application as catalysts in stereoselective reactions

“…The election method for the preparation of 1-(aminoalkyl)naphthols is the aminoalkylation of electron rich aromatic compounds, [52][53][54][55][56][57][58][59][60][61][62][63] the aromatic version of the Mannich reaction, one of the most important multicomponent reactions in organic synthesis (Scheme 9). In the course of this three-component aminoalkylation of naphthols, CÀ ÀN and CÀ ÀC single bonds replace the C¼ ¼O double bond.…”

Synthesis of some new Betti bases via one-pot three-component reaction of β-naphthol, primary diamine and substituted aromatic aldehydes

“…In last years a similar reaction were achieved can by either using other naphthols (Pirrone,1940) or quinolinols (Phillips,1956) or by replacing ammonia with alkyl amines (Brode & Littman, 1930), (Wang & Ding, 2002), (Cardellicchio et al, 1999) and (Szatmari, 2003). In addition, a variety of racemic structures related to the Betti's bases have been synthesized recently by addition of naphthols to the preformed imminium salts (Grumbach et al,1996). In recent years, the effort were done to synthesized the Betti's base derivatives in organic solvents such as EtOH, MeOH, and Et2O at room temperature or thermally under solvent less condition .The literature also reveals that such compounds are gaining interest of chemists who are working in the field of asymmetric synthesis because of utility in preparation of chiral inductors or chiral precursor.…”