ChemInform Abstract: Amidines. Part 39. Formation of N¹,N¹‐Dialkylamidines in the Reaction Between Amide Acetals and Substituted Anilines in Pyridine. Reaction Mechanisms.

Abstract

1999 kinetics, optimization of reactions kinetics, optimization of reactions O 0010 -031Amidines. Part 39. Formation of N 1 ,N 1 -Dialkylamidines in the Reaction Between Amide Acetals and Substituted Anilines in Pyridine. Reaction Mechanisms.-Reaction of acetals (I) with anilines (II) in pyridine to yield the corresponding amidines (III)-(VI) is irreversible and obeys second-order kinetics. Pyridine has little influence on the rate of reaction of the acetals with strongly and moderately basic anilines, but in reactions with weakly basic nitroanilines, it is the most convenient solvent and causes significant increase in reaction rates. -(OSZCZAPOWICZ, J.; OSEK, J.; J.