ChemInform Abstract: A Transition‐Metal‐Controlled Synthesis of (.+‐.)‐Aristeromycin and (.+‐.)‐2′,3′‐diepi‐Aristeromycin. An Unusual Directive Effect in Hydroxylations.

Abstract

The palladium catalyzed alkylation of the pyrimidinone (III) with the vinyl epoxides (II) or (IV) proceeds with great regioselectivity to yield either the 1,2‐adduct (I) or the 1,4‐adduct (V).