ChemInform Abstract: A Synthetic Application of β‐Aminoalanines to Some New 5‐Dialkylaminomethyl‐3‐phenylhydantoin Derivatives.

Abstract

Hydantoin derivatives R 0210A Synthetic Application of β-Aminoalanines to Some New 5-Dialkylaminomethyl-3-phenylhydantoin Derivatives. -Nucleophilic addition of β-aminoalanines to phenyl isocyanate (II) yield the carbamoylaminoalanines (III) which upon treatment with concentrated HCl easily cyclize into hydantoins (IV). Treatment of hydantoin derivative (IVd) with a large excess of water leads to deamination product (V). Furthermore, the exchange reaction of the amine moiety can also be applied to prepare urea derivatives, cf. (IVe) → (IIIb), (IIIc). -(FUJISAKI, F.; SHOJI, K.; SUMOTO*, K.; Heterocycles 78 (2009) 1, 213-220; Fac. Pharm. Sci., Fukuoka Univ.,