ChemInform Abstract: A Simple and Effective Synthesis of Benzolactones and Benzolactams by Noncatalytic Benzylic Oxidation of Cyclic Benzylic Ethers and N‐Protected Cyclic Benzylic Amines with Sodium Chlorite as an Oxidant.

Oxidative α-Functionalization of 1,2,3,4-Tetrahydroisoquinolines Catalyzed by a Magnetically Recoverable Copper Nanocatalyst. Application in the Aza-Henry Reaction and the Synthesis of 3,4-Dihydroisoquinolones

“…Another useful process for the functionalization at C-1 of the THIQ core is the α-oxidation to give 3,4-dihydroisoquinolones, thereby enabling access to valuable structural scaffolds found in many natural and synthetic products of pharmaceutical relevance . While the most attractive and atom-economic way for the synthesis of 3,4-dihydroisoquinolones is the direct α-oxidation of THIQs, traditional methods for their synthesis often consist of multistep processes. ,, Even when the formation of dihydroisoquinolones has been observed as byproducts in some THIQ α-substitution reactions, the direct α-oxidation of THIQs remains a challenge, and only a few reports appear in the literature regarding this significant transformation, most of them based on the application of photocatalytic methods. ,− , …”