ChemInform Abstract: A Review of the Plants of the Genus Phyllanthus: Their Chemistry, Pharmacology, and Therapeutic Potential

Calixto, João Β.; Santos, Adair Roberto Soares; Filho, Valdir Cechinel; Yunes, Rosendo A.

doi:10.1002/chin.199838321

Cited by 129 publications

(164 citation statements)

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“…The extract tested positive for alkaloids, tannins, terpenoids, reducing sugars and flavonoids, and negative for saponins, anthraquinones, and cardiac glycosides. The observed phytochemical profile of P. serpentinicola is similar to that of other Phyllanthus species (Calixto et al, 1998).…”

Section: Discussionsupporting

confidence: 68%

“…Phytochemical and pharmacological evaluation of several Phyllanthus species has identified a number of useful biologically active compounds. Phyllanthimide, an alkaloid used as a model for the synthesis of cystostatic agents in treatment of cancer is one of several useful compounds derived from Phyllanthus (Calixto et al, 1998). Phyllanthus species reportedly have antipyretic, analgesic, anti-inflammatory, antihepatotoxic and antiviral activities (Unander et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Phyllanthus species reportedly have antipyretic, analgesic, anti-inflammatory, antihepatotoxic and antiviral activities (Unander et al, 1990). Phytochemical and pharmacological profiles of Phyllanthus show variability according to species and environmental conditions (Calixto et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

Zimudzi¹

2012

J. App. Pharm. Sci.

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Stem methanolic extract of Phyllanthus serpentinicola was screened for phytochemicals, and tested for cytotoxicity and anti-inflammatory activities. Tests indicated presence of alkaloids, tannins, terpenoids, reducing sugars and flavonoids. Saponins, anthraquinones, and cardiac glycosides were absent. Cytotoxic effects of the plant were assessed through Brine shrimp lethality (BSL) bioassay. An LC 50 value of 1.3 µg/ml was found, thus indicating that the stem extract was strongly cytotoxic. Anti-inflammatory activity was assessed by the egg albumen induced hind paw oedema test on Swiss albino mice. The extract significantly (p<0.05) reduced the oedema, thus indicating that P. serpentinicola has anti-inflammatory properties.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

Zimudzi¹

2012

J. App. Pharm. Sci.

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“…Several species from this genus are used worldwide in folk medicine for diverse therapeutic purposes. Pre-clinical pharmacological studies carried out with extracts and purified compounds from Phyllanthus species support most of their reported uses in folk medicine (Calixto et al, 1998). The popular uses of Phyllanthus species reported the treatment of dysentery, gonorrhea, urinary discharges, kidney and bladder stones (Unander et al, 1995).…”

Section: Introductionmentioning

confidence: 89%

Anti-inflammatory, antiallodynic effects and quantitative analysis of gallic acid in spray dried powders from Phyllanthus niruri leaves, stems, roots and whole plant

Couto¹,

Kassuya²,

Calixto³

et al. 2013

Rev. bras. farmacogn.

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Abstract:The anti-inflammatory and antiallodynic effects of spray dried powders starting from leaves, stems, roots, the mixture of leaves and stems, as well as the whole plant aqueous solutions of Phyllanthus niruri L., Phyllanthaceae, were assessed. Gallic acid, used as chemical marker, was quantified by HPLC in the spray dried powders. Carrageenan-induced inflammatory and allodynic responses in the mouse paw were used as pharmacological models. Quantitative and qualitative differences among chemical composition of different herb parts were observed. The oral administration of leaves or leaves plus stems spray dried powders (100 mg/kg) significantly inhibited the carrageenan-induced allodynic effect (42±5 and 54±3%, respectively). Additionally, the spray dried powders of leaves significantly reduced carrageenan-induced paw oedema (35±6%). The spray dried powders of roots, stems, or the mixture of leaves, stems and roots (100 mg/kg, p.o.) did not exhibit antiallodynic or antioedematogenic effect in the same model. In conclusion, differences in the chemical composition of spray dried powders from P. niruri are reflected in their in vivo pharmacological actions. Despite of a direct relationship of anti-inflammatory and antiallodynic effects with the gallic acid content had been observed, especially in the spray dried powders of leaves, the use of spray dried powders of leaves plus stems showed to be more effective, suggesting a synergic effect between their constituents.

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“…Several classes of chemicals have been found in P. niruri, including lignans, alkaloids, benzenoids, coumarins, lipid, sterol, tannin, terpenes, saponins and flavonoids [72]. A few flavonoid from P. niruri that have been reported so far include quercetin, rutin, astragalin, quercitrin, isoquercitrin, kaempferol-4'-rhamnopyranoside, fisetin-4-o-glucoside and nirurin [73,74]. Harish & Shivanandappa [72] investigated the antioxidant activity and hepatoprotective potential of P. niruri.…”

Section: Tpc and Tfc Of O Stamineus And P Niruri Extractsmentioning

confidence: 99%

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

Alias¹,

Leow²,

Ali³

et al. 2017

AOWMC

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Natural products are a vast source of potential compounds that can be developed as anti-obesity agent. One of the mechanisms of anti-obesity agents is inhibition of pancreatic lipase. Assay of 24 crude extracts for their in vitro activity against porcine pancreatic lipase (PPL) detected four extracts demonstrating high (>70%) inhibition, seven extracts had medium (30-70%) inhibition and the remaining 13 extracts exhibited low (<30%) inhibition when incubated with PPL at a concentration of 500 µg/ml for 10 min at 37°C. Phyllanthus niruri extract displayed the most potent PPL inhibitor, followed by Orthosiphon stamineus, Murraya paniculata and Averrhoa bilimbi with the IC50 value of 27.7<34.7< 41.5<55.2 µg/ml, respectively. P. niruri & O. stamineus (the best two extracts) showed noncompetitive and uncompetitive inhibition, respectively. P. niruri & O. stamineus displayed total phenolic content of 431.0 ± 0.01 and 103.0 ± 0.01 mg GAE/g dry extract, while total flavonoid content of 14.8 ± 0.07 and 21.6 ± 0.03 mg QE/g dry extract, respectively. Both P. niruri & O. stamineus extracts showed high antioxidant activity, with EC50 values of 8.4 and 26.3 µg/ml, respectively. The results suggest that P. niruri & O. stamineus may be beneficial for obesity treatment via pancreatic lipase inhibition action.

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ChemInform Abstract: A Review of the Plants of the Genus Phyllanthus: Their Chemistry, Pharmacology, and Therapeutic Potential

Abstract: A Review of the Plants of the Genus Phyllanthus: Their Chemistry, Pharmacology, and Therapeutic Potential -[218 refs.]. -(CAL-IXTO, J. B.; SANTOS, A. R. S.; CECHINEL FILHO, V.; YUNES, R. A.; Med.

Cited by 129 publications

References 1 publication

Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

Anti-inflammatory, antiallodynic effects and quantitative analysis of gallic acid in spray dried powders from Phyllanthus niruri leaves, stems, roots and whole plant

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

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