ChemInform Abstract: A Practical Synthesis of the Cyclohexyl Part of the Immunosuppressant FK506.

Abstract

A Practical Synthesis of the Cyclohexyl Part of the Immunosuppressant FK506.-Starting from the known lactone (I), derived from D-(-)-quinic acid, an efficient approach to the title compound (XIII) is developed, which is also useful for a large-scale synthesis. -(HALLER, B.-U.; KRUBER, S.; MAIER, M. E.; J. Prakt. Chem./Chem.-Ztg. 340 (1998) 7, 656-661; Inst. Org. Chem., Eberhard-Karls-Univ.,