ChemInform Abstract: A Practical, Metal‐Free Synthesis of 1H‐Indazoles.

Abstract

Pyrazole derivatives R 0180A Practical, Metal-Free Synthesis of 1H-Indazoles. -Cyclization of o-aminobenzoximes (I) proceeds smoothly in the presence of MesCl-Et 3 N by selective activation of the oxime in the presence of an amino group to afford indazoles (II). Mild reaction conditions are applied and a variety of substituents at both the oxime and amine group is tolerated. -(COUNCELLER, C. M.; EICHMAN, C. C.; WRAY, B. C.; STAMBULI*, J. P.; Org. Lett. 10 (2008) 5, 1021-1023; Dep. Chem., Ohio State Univ., Columbus, OH 43210, USA; Eng.) -Mischke 32-118