ChemInform Abstract: A Practical Enzymatic Method for Preparation of (S)‐Ketoprofen with a Crude Candida rugosa Lipase.

Abstract

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Kinetic resolution of (R/S)-propranolol (1-isopropylamino-3-(1-naphtoxy)-2-propanolol) catalyzed by immobilized preparations of Candida antarctica lipase B (CAL-B)

“…This relative enzyme low specificity contrasts in some cases, with a high regio-and enantioselectivity [1,2]. Otherwise, these properties have allowed to use them, for example, for obtaining pure enantiomerically chemical compounds [3][4][5][6][7][8]. Lipases have a very interesting biocatalytical mechanism in aqueous solutions and in the presence of hydrophobic interfaces, displaying a conformational equilibrium between an open and closed form of the enzyme molecule [9][10][11][12].…”