ChemInform Abstract: A Novel Class of Cardiotonics. Synthesis and Pharmacological Properties of (4‐(Substituted‐Amino)phenyl)pyridazinones and Related Derivatives.

Abstract

The amine (I) is coupled with the heterocyclic halides (II), producing the derivatives (III) via SN‐reaction.

An efficient one‐pot synthesis of pyridazinones and phthalazinones using HY‐zeolite

“…Pyridazinones are useful compounds with a broad array of biologically activities. They possessed notable hypertensive [1], platelet aggregation inhibiter [2], phosphodiesterase [3], antiasthmatic [4], antisecretory and antiulcer [5], antidepressant [6], antibacterial [7], antifungal [8], α‐adrenoceptor antagonists [9], analgesic [10], anti‐inflammatory [11], antianemic [12], nephrotropic [13], cardiotonic [14], anticancer [15], and pesticidal and herbicidal [16] properties.…”