Abstract:Pyrazine derivatives R 0550A Novel Base-Mediated Intramolecular Hydroamination to Build Fused Heteroaryl Pyrazinones. -The procedure for the synthesis of title compounds (II), (IV) and (VI) is based on the DBU-mediated cyclization of amides of type (I), (III), and (V) where mixtures of double bond isomers (endo/exo-E, exo-Z) are formed. Their treatment according to B) renders possible the isolation of the thermodynamically most stabe isomer with concomitant loss of the -Dmb protecting group. -(LLAUGER*, L.; BE… Show more
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