ChemInform Abstract: A New Heck Reaction Modification Using Ketone Mannich Bases as Enone Precursors: Parallel Synthesis of anti‐Leishmanial Chalcones.

Abstract

Precursors: Parallel Synthesis of anti-Leishmanial Chalcones. -A series of chalcones (III) (11 examples) is prepared by Heck reaction of Mannich bases (I) with aryl iodides (II). Compounds (IIIe) and (IIIf) demonstrate potent anti-leishmanial activity. -(REICHWALD, C.; SHIMONY, O.; SACERDOTI-SIERRA, N.; JAFFE, C. L.; KUNICK*, C.; Bioorg. Med.