ChemInform Abstract: A New General Approach to Enantiomerically Pure Cyclic and Open‐Chain ( R)‐ and (S)‐α,α‐Disubstituted α‐Amino Acids.

Obrecht, Daniel; Spiegler, Clive; Schoenholzer, P.; Mueller, K.; Heimgartner, Heinz; Stierli, F.

doi:10.1002/chin.199248064

Cited by 2 publications

(2 citation statements)

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“…In mammalian systems, molecular oxygen is directly incorporated in naphthalene metabolism [13], thus 1, 2, 3, 4-tetrahydronaphthalene nucleus may undergo biological oxidation to furnish a quinonoid structure which may also take a part in the reduction of living cell anaerobic glycolysis rate [14]. Recently, it has been reported that several tetrahydronaphthyl heterocycles posses potent anticancer activity against liver and breast cancer [15] and good precursors for the synthesis of various antidepressants [16], natural alkaloids (17), cyclic amino acids (18) and novel antagonists [19] of human TRPVI. Also, we cannot overlook the importance of chalcones and their cyclized analogues which were reported to have various chemotherapeutic activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

Haiba

Al‐Abdullah

Hilmy

2013

ACSJ

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This work was carried out in collaboration between the authors. Author MEH carried out theSynthesis and the protocol for synthetic pathway managed the analysis of the study and spectroscopic evaluation and wrote the first draft. Author ESA designed the scheme and did the collation of the data and editing of the write-up. Author NMH shared in X-ray explanation and contribute in the analysis of the study and spectroscopic evaluation. All authors read and approved the final manuscript

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Section: Introductionmentioning

confidence: 99%

Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

Haiba

Al‐Abdullah

Hilmy

2013

ACSJ

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“…It was also used as a precursor to quinolines with dopaminergic activity, naphthols with anti-inflammatory activity and benzophenanthridine alkaloids with antitumor activity [124]. It has been used to synthesize natural alkaloids, cyclic amino acids and as novel antagonists of human TRPVI [125][126][127][128]. It was also used as a precursor to quinolines with dopaminergic activity, naphthols with antiinflammatory activity and benzophenanthridine alkaloids with antitumor activity.…”

Section: 7-dimethoxy-2-tetralone (C12h14o3)mentioning

confidence: 99%

Phytochemicals of algae, Arthospira platensis (spirulina) Chlorella vulgaris (chlorella) and Azolla pinnata (azolla)

Thangaraj¹,

Saravana²,

Jayakumar³

et al. 2022

GSC Biol. and Pharm. Sci.

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The present investigation was carried out to understand the proximate composition, and the secondary phytochemical compounds and their metabolites present in algae, spirulina, chlorella and azolla. Spirulina contains a rich source of crude protein (58.94%), followed by chlorella (47.08%) and azolla (21.82%). The content of crude fat was higher in chlorella (5.68%), followed by azolla (4.00%) and spirulina (1.54%). The crude fibre level was found to be higher in azolla (26.21%), followed by chlorella (2.87%) and spirulina (1.00%). The gross energy was higher in chlorella (4,377 kcal/kg), followed by spirulina (4,183 kcal/kg) and azolla (3,295 kcal/kg). The secondary phytochemical analysis revealed presence of alkaloids, terpenoids, flavonoids, tannis, polyphenols, saponins, cardiac glycoside and quinones in these algae at different levels. The GC-MS analysis showed presence of 11 metabolic compounds, of which 5 from petroleum etheric extract and 6 from methanolic extract. The chlorella showed presence of 14 secondary metabolites, of which 5 from petroleum etheric extract and 9 from methanolic extract. In azolla, there were 13 secondary metabolic compounds, of which 6 from petroleum etheric extract and 7 from methanolic extract. Therefore, a total of 38 secondary metabolites, which includes 12 different bioactive principle compounds, were identified in these algae. Docosane was found to be present both in spirulina and azolla. Similarly, Tetradecanoic acid was found to be present both in spirulina and chlorella. The remaining ten bioactive principle compounds are species specific, such as 9-octadecenal; and Hexadecanoic acid are for spirulina, Dodecanoic acid; 6,7-Dimethoxy-2-tetralone; 3,7,11,15-Tetramethyl-2-hexadecen-1-ol; Phenol, 2-methoxy-5-(1-propenyl)-,(E); Cycloheptane,1,3,5-tris(methylene); 4-(6,6-Dimethyl-2-methylenecyclohex-3-enylidene)pentan-2-ol; and Loliolide are for chlorella, and cis-2-[2-(hydroxymethyl)cyclopentyl]ethanol is for azolla. Thus, these algae are rich in natural organic compounds. Their pharmaceutical and nutraceutical potencies need to be studied.

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ChemInform Abstract: A New General Approach to Enantiomerically Pure Cyclic and Open‐Chain ( R)‐ and (S)‐α,α‐Disubstituted α‐Amino Acids.

Cited by 2 publications

References 1 publication

Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives

Phytochemicals of algae, Arthospira platensis (spirulina) Chlorella vulgaris (chlorella) and Azolla pinnata (azolla)

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