ChemInform Abstract: A New Asymmetric Synthesis of the Antitumor Alkaloid (R)‐(+)‐Crispine A.

Abstract

A New Asymmetric Synthesis of the Antitumor Alkaloid (R)-(+)-Crispine A. -A facile synthesis of title compound (I) is based on a diastereoselective N-acyliminium cyclization reaction as the key step. -(ALLIN*, S. M.; GASKELL, S. N.; TOWLER, J. M. R.; PAGE, P. C. B.; SAHA, B.; MCKENZIE, M. J.; MARTIN, W. P.; J. Org. Chem. 72 (2007) 23, 8972-8975; Dep. Chem., Loughborough Univ., Loughborough, Leicestershire LE11 3TU, UK; Eng.) -Nuesgen 10-225