“…The high efficiency, operational simplicity, minimum reaction time, outstanding yields, high rate, and environmental safety are noticeable advantages of this procedure (Scheme 16). [67] Gupta et al established two efficient, very simple, and environmentally benign protocols for synthesis of (3) catalyst free, solid support, simply by microwave irradiation at 300 W or heating at 120 °C mixtures of (2) and aldehyde (1) in 2 : 1 mole ratio (Scheme 17). [68] Kumar et al have devised an effective, inexpensive, and environmentally sustainable amphiphile-catalyzed multicomponent reaction of (2) aromatic aldehydes (1) and secondary amines (10) in an aqueous medium catalyzed one-pot synthesis of (3) through a Knoevenagel-Michael type reaction(Scheme 18).…”