ChemInform Abstract: A Green, Facile Approach for the Multicomponent Synthesis of Bioactive Spiro[indoline‐3,7′‐pyrrolo[1,2‐c]imidazole] Derivatives.

Abstract

A Green, Facile Approach for the Multicomponent Synthesis of Bioactive Spiro[indoline-3,7'-pyrrolo[1,2-c]imidazole] Derivatives. -A variety of the title spiro-compounds (IV) (17 examples) are synthesized via a NaHCO 3-catalyzed three-component reaction. Some of them, e.g. compound (IVf), show much higher activities in the screening for the cell division cycle 2 phosphatase B (CDC25B) than the standard drug Na3VO4. -(SHEN, T.; ZHOU, Y.; CHE, F.; YU, J.; LIN, Y.; SONG*, Q.; J. Chem. Res. 39 (2015) 2, 115-119, http://dx.doi.org/10.3184/174751915X14229612721445 ; State Key Lab. Breed.