Abstract:A Facile One-Pot Synthesis of 3,5-Disubstituted Isoxazole Derivatives Using Hydroxy (Tosyloxy) Iodobenzene. -The reaction of aromatic aldoximes with aliphatic and aromatic alkynes in the presence of a hypervalent iodine reagent proceeds via an in situ generated reactive nitrile oxide intermediate to provide a direct access to disubstituted isoxazoles. The use of the iodine reagent is of limited utility for synthesizing isoxazoles possessing electron-donating substituents on the aromatic nucleus. The advantage … Show more
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