ChemInform Abstract: A Comparison of Several Modern Alkylating Agents

Abstract

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N-methylimidazole mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions

“…The fact that DMAD and DEAD reacted showed that the displacement step could have S N 2 character. 17 EXPERIMENTAL Microwave irradiation was performed with a Milestone ETHOS 1600 microwave oven. The chemicals were purchased from Fluka and used without further purification.…”

Recent Advances in Methylation: A Guide for Selecting Methylation Reagents

“…MeOTf and its perfluoro analogs such as methyl nona‐fluorobutyl‐1‐sulfonate (MeONf) are powerful reagents for methylation and are more reactive by a factor of approximately 10 4 than methyl iodide and Me 2 SO 4 . In many cases, they are used as N‐, O‐, or S‐methylation reagents under basic conditions. The literature on the uses of these methyl sulfonates as methylation reagents are very profuse .…”

“…Several recent reviews on methylation focused on different aspects, for example, using dimethyl carbonate as the methylation reagent, carbon dioxide for transition‐metal‐free catalysis for N‐methylation, peroxides, other radical sources to generate the methyl radical, metal‐catalyzed methylation, decarboxylative methylation, the use of methanol in Mitsunobu reactions, hydrogen borrowing strategies, nickel‐catalyzed reductive couplings of alkyl electrophiles, cross‐coupling methods for C‐methylation, and photoredox catalysis . In 2009, Lamoureux and Agüero published a review comparing several alkylating agents . Among other reviews, the one by Aurelio and Hughes is noteworthy.…”

Dimethyl sulfite a potential agent for methylation

“…1 Methylethers are considered as good oxygenated molecules due to their capacity to reduce CO emission, and to enhance gasoline combustion increasing octane numbers. They also exhibit excellent properties as solvents for extractions, and are used in several applications such as coatings, inks, paints, cleaning agents and pharmaceuticals.…”