ChemInform Abstract: A Comparative Study of Synthetic Approaches to 1‐Methyl‐2,5,8(1H)‐ quinolinetrione and 4‐Methyl‐2,5,8(1H)‐quinolinetrione.

Avendaño, Carmen; Cuesta, Elena de la; Gesto, C.

doi:10.1002/chin.199211179

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8-dimethoxy-4-methylquinolin-2(1h)-one (1k1

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2009

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“…This compound was prepared in 84% yield as a light-brown solid by following method A: mp 187−189 °C (lit . mp 188−189 °C).…”

Section: Methodsmentioning

confidence: 99%

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Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities

et al. 2009

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An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogs has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents.

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“…This compound was prepared in 84% yield as a light-brown solid by following method A: mp 187−189 °C (lit . mp 188−189 °C).…”

Section: Methodsmentioning

confidence: 99%

“…This compound was prepared in 84% yield as a light-brown solid by following method A: mp 187-189 °C (lit. 30 (32), 148 (12), 133 (23), 120 (5), 104 (9), 89 (6), 77 (8). HRMS calcd for C 12 H 13 NO 3 219.0895, found 219.0896.…”

Section: 8-dimethoxy-4-methylquinolin-2(1h)-one (1kmentioning

confidence: 99%