ChemInform Abstract: A Catalytic, Broensted Base Strategy for Intermolecular Allylic C—H Amination.

Abstract

A Catalytic, Broensted Base Strategy for Intermolecular Allylic C-H Amination.-The mild activation mode enables the presence of sensitive moieties such as terminal epoxides and unprotected alcohols in the allylated starting materials and late-stage incorporation of nitrogen into advanced synthetic intermediates and natural products. Furthermore, overall product yields under the DIPEA conditions are consistently higher than those under conditions employing Cr/benzoquinone. -(REED, S. A.; MAZZOTTI, A. R.; WHITE*, M. C.; J.