ChemInform Abstract: 6,7‐Seco‐ent‐Kaurane‐Type Diterpenoids from Isodon eriocalyx var. laxiflora.

Abstract

6,7-Seco-ent-Kaurane-Type Diterpenoids from Isodon eriocalyx var. laxiflora. -The isolation, structure elucidation and bioevaluation of twenty nine 6,7-seco-ent-kaurane-type diterpenoids including 18 new ones, laxiflorolides C-T [structure examples (I)-(V)] is described. Laxiflorolide C (I) shows selective cytotoxic activity against HL-60 and SW-480 cells and strong inhibitory activity against NO production. -(WANG, W.-G.; YAN, B.-C.; LI, X.-N.; DU, X.; WU, H.-Y.; ZHAN, R.; LI, Y.; PU*, J.-X.; SUN, H.-D.; Tetrahedron 70 (2014) 41, 7445-7453, http://dx.