ChemInform Abstract: 4‐Hydroxy‐3‐quinolinecarboxamides with Antiarthritic and Analgesic Activities.

Abstract

The N'‐2‐thiazolyl‐4‐hydroxyquinolinecarboxamides (III) and (VI) are prepared by coupling of the quinolinecarboxylic acids (I) or the acyl chlorides (V) with 2‐aminothiazole (II).

Synthesis and pharmaceutical applications of Oxazine compounds derived from Pyronic, Salicylic, Antharanilic acids and Phenols

“…There are a lot of methods in the literature concerning the synthesis of oxazine compounds from antharanilic acid by ring closure either by acetic anhydride [28,29] or chloro acetyl chloride [30] or succinic anhydride [31] or alkyl chloro acetate [32] and ethyl ester derivatives [33] such as cynao ethyl ester. There were also other methods found in the literature for synthesizing of 1,3-oxazine other than the mentioned above [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] some of them have antimicrobial activities among other than anthranilic acid precursors for oxazine synthesis are the following: Amidosalysilate [50,51]. These compounds were cyclized either by tosyl chloride, isothiocyante, pyridine and chloroformate [52][53][54][55] and Vilsmeier-Haack reaction [56,57].…”

Teaching an Old Dog New Tricks: Simple Selective and Regiodivergent Quinoline Hydrogenation

“…In this respect, hydrogenation of quinoline is a well-studied example of such reactions. Aside from the rich chemistry of quinoline substrates ( vide infra ), their hydrogenation products find applications in agrochemicals, pharmaceuticals, petrochemicals, and fine chemicals. − Furthermore, N-heterocyclic compounds, including quinoline derivatives, are becoming increasingly popular as so-called liquid organic hydrogen carriers (LOHCs). − …”