ChemInform Abstract: 3H‐1,2‐Benzodithiole‐3‐one 1,1‐Dioxide as an Improved Sulfurizing Reagent in the Solid‐Phase Synthesis of Oligodeoxyribonucleoside Phosphorothioates.

Abstract

Phosphorothioate oligodeoxyribonucleotides are known to be resistant to degradation by nucleases, and, hence, have demonstrated their usefulness as "antisense" molecules by inhibiting gene expression in vitro.