ChemInform Abstract: 3‐Arylcoumarins: Synthesis and Potent Antiinflammatory Activity.

Abstract

3-Arylcoumarins: Synthesis and Potent Antiinflammatory Activity. -Thirty five 3-arylcoumarins (III) are prepared via Perkin condensation. New derivatives (IIIc) and (IIIf) exhibit potent nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse macrophage RAW264.7 cells. -(PU, W.; LIN, Y.; ZHANG, J.; WANG, F.; WANG, C.; ZHANG*, G.; Bioorg. Med. Chem. Lett. 24 (2014) 23, 5432-5434, http://dx.