ChemInform Abstract: 2‐Oxazol‐5‐ylethanones by Consecutive Three‐Component Amidation—Coupling—Cycloisomerization (ACCI) Sequence.

Abstract

Oxazole derivatives R 0220 2-Oxazol-5-ylethanones by Consecutive Three-Component Amidation-Coupling-Cycloisomerization (ACCI) Sequence. -(MERKUL, E.; GROTKOPP, O.; MUELLER*, T. J. J.; Synthesis 2009, 3, 502-507; Inst. Org. Chem. Makromol. Chem., Heinrich-Heine-Univ., D-40225 Duesseldorf, Germany; Eng.) -Mais 24-121

Acyl Sonogashira Cross-Coupling: State of the Art and Application to the Synthesis of Heterocyclic Compounds

“…The oxazole and isoxazole moieties are common heterocyclic motifs identified in many natural products and biologically active compounds. An efficient three steps synthesis of 2,5-polyfunctionalized oxazole derivatives was developed by Müller's group [91,92] starting from acyl chlorides and propargyl amine. The first reaction consisted in an amidation of the acid chloride promoted by Et 3 N, followed by in situ Sonogashira cross-coupling of the generated alkynyl amide with another equivalent of RCOCl.…”