Abstract:2-Fluoro-2-buten-4-olide, a New Fluorinated Synthon. Preparation; 1,2-1,4-, and Tandem Additions.-The title compound (VI) is prepared either from D-erythronolactone (I) or by Wittig-Horner reaction of the fluoroacetate (VII). It undergoes 1,2-addition with hard nucleophiles (X) andXII) and 1,4-addition by soft carbon nucleophile derived from (XIV) to the β-alkylated 2-fluorobutan-4-olides (XV)/(XVI). -(KVICALA, J.; PLOCAR, J.; VLASAKOVA, R.; PALETA, O.; PELTER, A.; Synlett (1997) 8, 986-988; Dep. Org. Chem., P… Show more
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