ChemInform Abstract: 2‐Azetidinone Derivatives: Design, Synthesis, in vitro Antimicrobial, Cytotoxic Activities and DNA Cleavage Study.

Keri, Rangappa S.; Hosamani, Kallappa M.; Shingalapur, Ramya V.; Reddy, Harisha R. Seetharama

doi:10.1002/chin.201017143

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2011

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“…Moreover, due to their b-lactamase inhibitory action, 2-azetidinone-based heterocycles represent an attractive target of contemporary organic synthesis. A large numbers of 2-azetidinones (Arnould et al, 1992;Halve et al, 2007;Keri et al, 2009) were reported to possess antibacterial and antifungal activity. The 4-thiazoldinone nucleus has drawn many attentions due to its various activities like antimicrobial (Vicini et al, 2008), anti-HIV (Chen et al, 2009;Rao et al, 2004;Rawal et al, 2005) anticancer (Abdel-Aziz et al, 2010;Lv et al, 2010) and antihypertensive (Bhandari et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial activity of 5-chloroindoline-2,3-dione derivatives

Shingade

Bari

Waghmare³

2011

Med Chem Res

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A series of 3-(5-chloro-2-oxoindolin-3-ylideneamino)-2-arylthiazolidin-4-ones 4a-k and 5-chloro-3-(3-chloro-2-oxo-4-arylazetidin-1-ylimino)indolin-2-ones 5a-k was synthesized. The structures of final compounds were confirmed by analytical (C, H, N) and spectral (FT-IR, 1 H NMR, 13 C NMR and Mass) data. The synthesized compounds were screened for possible antibacterial and antifungal activity. Compounds 4c, 4f, 4g, 4h, 4i, 4j, 5c, 5f, 5g, 5h, 5i and 5j showed substantially significant activity.

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