ChemInform Abstract: 2‐Amino‐3‐substituted‐6‐ [(E)‐1‐phenyl‐2‐(N‐methylcarbamoyl)vinyl]imidazo‐[1,2‐a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity.

Abstract

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Highly Regioselective, Acid-Catalyzed, Three-Component Cascade Reaction for the Synthesis of 2-aminopyridine-Decorated Imidazo[1,2-a]pyridine

“…C onsiderable efforts have been devoted to developing new imidazo[1,2-a]pyridine-based heterocycles compounds, 1−4 that is, a single compound that displays the coexistence or synergism of two or more properties including obvious inhibitory effects on many target enzymes 5−7 and good bioactivity in the aspect of antitumor, 8−12 antivirus, 13−15 antibacterial, 16−18 antituberculosis, 19,20 anti-inflammatory, 21 antiulcer, 22 antidiabetic, 23 antipsychotic, 24,25 etc. 3-Substituted imidazo [1,2-a]pyridines are of particular interest, because of their potential applications in many commercially available drugs such as necopidem, alpidem, saripidem, and minodronic acid.…”

Synthesis and Evaluation of Photophysical Properties of C‐3 Halogenated Derivatives of 2‐Phenylimidazo[1,2‐a]pyridine

“…The imidazole‐fused pyridine heteroaromatic motif is an important structural scaffold in many bioactive compounds. Compounds containing imidazo[1,2‐ a ]pyridine nucleus have a variety of biological activities and pharmacological effects, including anti‐ ulcer, [ 1‐2 ] anti‐tumor, [ 3‐4 ] anti‐inflammatory, [ 5‐6 ] antipyretic [ 7‐9 ] activities, and treatment of neurological diseases. Especially, different substituents on C‐3 position of imidazo[1,2‐ a ]pyridine will directly affect its biological activity.…”