ChemInform Abstract: 2,6‐Piperidinediones. Part 4. Syntheses of the Racemates and the Enantiomers of 3,3‐Disubstituted 2,6‐Piperidinediones with Basic Side Chains.

Abstract

ChemInform Abstract The piperidinediones (IV) are prepared from the nitriles (I) and (V) as shown in the reaction scheme. The racemic compounds (IVa) -(IVc) and (IVd) are optically resolved using bis(bi-1,1'-(naphth-2-yl))phosphoric acid. Hydrogenation of the racemate and the enantiomers of (IVa) in the presence of rhodium on carbon gives the amines (X). Further conversions such as N-methylation of (IVb) and (IVc) are described in the original paper.