ChemInform Abstract: 1‐Substituted 5‐Dialkylaminomethyl‐1,5,6,7‐tetrahydroindazol‐4‐ones with Antiinflammatory and Analgesic Activity.

Mosti, Luisa; Menozzi, Giulia; Schenone, P; Tortora, Gelsomina; Mauro, Giovanni Di; Lama, Maria Perpetua Freire de Morais Del; Marmo, E

doi:10.1002/chin.198744184

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Indazoles As Anti-inflammatory Agents1

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2011

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“…[(1-phenyl-1H-indazol-4-yl)oxy]acetic acid (9) and 5-benzyl-1-phenyl-1H-indazol-4-ol (10) were synthesized using 1,5,6,7-Tetrahydro-1-phenyl-4H-indazol-4-one (Mosti et al, 1987(Mosti et al, , 1988(Mosti et al, , 1992. The synthesized compounds were tested and found to have good anti-inflammatory activity in rats, and analgesic activity in mice similar to that of Indomethacin.…”

Section: Indazoles As Anti-inflammatory Agentsmentioning

confidence: 99%

Indazole: a medicinally important heterocyclic moiety

et al. 2011

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This article reveals the various biological activities of the heterocyclic compound, indazole, including anti-inflammatory, antimicrobial, antiHIV, anticancer, hypoglycemic, antiprotozoal, antihypertensive, and other activities. From the observed biological activities of the indazole moiety, it is concluded that the medicinal properties of indazole have to be explored in the near future for the treatment of various pathological conditions.

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Section: Indazoles As Anti-inflammatory Agentsmentioning

confidence: 99%