ChemInform Abstract: 1‐ALKYL(AND 1‐GLUCOSYL)IMIDAZOLE‐4,5‐DICARBOXYLIC ACID DIAMIDES

Aleksandrova, I. Ya.; Khrustaleva, V. S.; Khromov‐Borisov, N. V.

doi:10.1002/chin.198328195

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2000

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“…1 supplemented with 5 mM (or 50 ~tM) L-aspartic acid and 10 ~tM glycine. IEM-1573, IEM-1442, IEM-1441, and IEM-1791 were synthesized by alkylation of the dimethyl ester of imidazole-4,5-dicarboxylic acid followed by hydrolysis, as described in [1]. IEM-1574, IEM-1808, IEM-1795, and IEM-1797 were prepared by oxidation of the corresponding 2-substituted benzimidazoles as described in [2,6,18].…”

Section: Solutions Andmentioning

confidence: 99%

A new class of agonists and antagonists of N-methyl-D-aspartic acid receptors: Derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids

Piotrovskii

Lishko²,

Maksimyuk³

et al. 2000

Neurosci Behav Physiol

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Studies of imidazole-4,5- and pyrazole-3,4-dicarboxylic acid derivatives revealed a number of new agonists and antagonists of N-methyl-D-aspartic acid (NMDA) receptors. Studies were based on whole-cell patch-clamp methods applied to rat hippocampus pyramidal cells. Increases in the lipophilicity of the environment of the nitrogen atom, keeping the distance between the terminal acid functions constant, led to a weakening of NMDA antagonism and increases in NMDA antagonism. Increases in the lipophilicity around the nitrogen atom could also lead to less of selectivity in the interaction with NMDA receptors and the appearance of non-NMDA antagonist properties.

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Section: Solutions Andmentioning

confidence: 99%

A new class of agonists and antagonists of N-methyl-D-aspartic acid receptors: Derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids

Piotrovskii

Lishko²,

Maksimyuk³

et al. 2000

Neurosci Behav Physiol

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ChemInform Abstract: 1‐ALKYL(AND 1‐GLUCOSYL)IMIDAZOLE‐4,5‐DICARBOXYLIC ACID DIAMIDES

Abstract: Einige Amide ′ der Imidazol‐4,5‐dicarbonsäure besitzen neurotrope Wirkung.

Cited by 1 publication

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A new class of agonists and antagonists of N-methyl-D-aspartic acid receptors: Derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids

A new class of agonists and antagonists of N-methyl-D-aspartic acid receptors: Derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids

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