ChemInform Abstract: 1‐(4‐(N,N‐Bis‐β‐chloroethylcarbamoyloxy)phenyl)‐1,2‐bis(hydroxyphenyl)but‐# 1‐enes: Drugs Specifically Targeted Against Estrogen Receptor Positive Mammary Tumors.

Abstract

Grignard reaction of the ketones (I) with the phenol ether (II) followed by simultaneous acidic elimination and removal of the O‐protecting group forms an E/Z‐mixture of the triarylbutenes (III).