Chemiluminescence and bioluminescence

McCapra, Frank

doi:10.1016/1010-6030(90)87037-c

Cited by 46 publications

(7 citation statements)

References 18 publications

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“…[37,38] Moreover,t he presence of oxidizable electron-rich moieties are insufficient for the efficient formation of singlet excited states, in both intra-and intermolecular CL reactions. [31,45,49] Based on these findings andf rom our own theoretical results, we have proposed the interstate-crossing-induced chemiexcitation (ICIC) mechanism. [33,37] We considert hat charge/ electron-transfer processes are important for the determination of the activation barrier for thermal decomposition, and not necessarily for the chemiexcitation step.…”

Section: The Molecular Mechanisms Of Chemiluminescencementioning

confidence: 91%

Chemiluminescence and Bioluminescence as an Excitation Source in the Photodynamic Therapy of Cancer: A Critical Review

2016

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Photodynamic therapy (PDT) of cancer is known for its limited number of side effects, and requires light, oxygen and photosensitizer. However, PDT is limited by poor penetration of light into deeply localized tissues, and the use of external light sources is required. Thus, researchers have been studying ways to improve the effectiveness of this phototherapy and expand it for the treatment of the deepest cancers, by using chemiluminescent or bioluminescent formulations to excite the photosensitizer by intracellular generation of light. The aim of this Minireview is to give a précis of the most important general chemi-/bioluminescence mechanisms and to analyze several studies that apply them for PDT. These studies have demonstrated the potential of utilizing chemi-/bioluminescence as excitation source in the PDT of cancer, besides combining new approaches to overcome the limitations of this mode of treatment.

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Section: The Molecular Mechanisms Of Chemiluminescencementioning

confidence: 91%

Chemiluminescence and Bioluminescence as an Excitation Source in the Photodynamic Therapy of Cancer: A Critical Review

2016

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“…[50] Currently, there are two mechanisms that try to rationalize the role of charge transfer in dioxetanone decomposition: chemically initiated electron-exchange luminescence (CIEEL) [51][52][53][54] and charge transfer induced luminescence (CTIL). [50] Currently, there are two mechanisms that try to rationalize the role of charge transfer in dioxetanone decomposition: chemically initiated electron-exchange luminescence (CIEEL) [51][52][53][54] and charge transfer induced luminescence (CTIL).…”

Section: Bioluminescence Reaction Mechanismmentioning

confidence: 99%

“…It is known that methylation of the benzothiazole oxygen atom greatly decreases the efficiency of bioluminescence, which indicates a role of intramolecular charge-transfer involving the phenolate anion in the formation of Keto-(À1). [50] Currently, there are two mechanisms that try to rationalize the role of charge transfer in dioxetanone decomposition: chemically initiated electron-exchange luminescence (CIEEL) [51][52][53][54] and charge transfer induced luminescence (CTIL). [55] In the CIEEL mechanism a radical ion pair is formed by electron transfer from the electron-donating fragment to the dioxetanone moiety.…”

Section: Bioluminescence Reaction Mechanismmentioning

confidence: 99%

Firefly Chemiluminescence and Bioluminescence: Efficient Generation of Excited States

Silva

2012

ChemPhysChem

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Firefly luciferase catalyzes a light-emitting reaction in which an excited-state product is formed. Both experimental and theoretical methodologies are used to study this system, and the reactions catalyzed by luciferase are relatively well characterized. However, the mechanism by which an excited-state product is formed is still unknown. This Minireview deals with the current understanding of firefly bioluminescence and chemiluminescence. Thermal decomposition of simple 1,2-dioxetanes is also discussed, due to their role in formation of the excited-state bioluminophore.

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“…Chemiluminescence (CL) is the spontaneous emission of light from an electronically excited state of a species produced by a chemical reaction [1]. Nature uses CL (called bioluminescence) in many living organisms such as fireflies, mushrooms, shells, jellyfish, [2] worms and bacteria, mainly for communication or defense roles [3]. In biological systems, bioluminescence occurs from in situ enzyme-catalyzed chemical transformations, for example luciferin [4] reacts with oxygen in the presence of luciferase enzyme [5], magnesium [6][7][8][9] or calcium ions and adenosine triphosphate (ATP), leading to luminescence [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

et al. 2021

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Emission of light by matter can occur through a variety of mechanisms. When it results from an electronically excited state of a species produced by a chemical reaction, it is called chemiluminescence (CL). The phenomenon can take place both in natural and artificial chemical systems and it has been utilized in a variety of applications. In this review, we aim to revisit some of the latest CL applications based on direct and indirect production modes. The characteristics of the chemical reactions and the underpinning CL mechanisms are thoroughly discussed in view of studies from the very recent bibliography. Different methodologies aiming at higher CL efficiencies are summarized and presented in detail, including CL type and scaffolds used in each study. The CL role in the development of efficient therapeutic platforms is also discussed in relation to the Reactive Oxygen Species (ROS) and singlet oxygen (1O2) produced, as final products. Moreover, recent research results from our team are included regarding the behavior of commonly used photosensitizers upon chemical activation under CL conditions. The CL prospects in imaging, biomimetic organic and radical chemistry, and therapeutics are critically presented in respect to the persisting challenges and limitations of the existing strategies to date.

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Chemiluminescence and bioluminescence

Cited by 46 publications

References 18 publications

Chemiluminescence and Bioluminescence as an Excitation Source in the Photodynamic Therapy of Cancer: A Critical Review

Chemiluminescence and Bioluminescence as an Excitation Source in the Photodynamic Therapy of Cancer: A Critical Review

Firefly Chemiluminescence and Bioluminescence: Efficient Generation of Excited States

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

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