Chemico-Pharmaceutical Analysis of the Biologically Active Substances Albicar

Berlyand, A. S.; Lebedev, O. V.; Прокопов, А. А.

doi:10.1007/s11094-013-0920-7

Cited by 17 publications

(5 citation statements)

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“…Some of them were integrated into medicine or recommended for clinical practice. These include the highly efficient daytime tranquilizer Mebicar (an achiral N -tetramethylglycoluril) and the low-toxic anxiolytic drug Albicar (a chiral trans- coordinated N -dimethyldiethylglycoluril). − …”

Section: Introductionmentioning

confidence: 99%

Standard Volumetric Properties of Chiral N-Methyl-Substituted Glycolurils in Water between 278.15 and 318.15 K at Ambient Pressure

Ivanov

2018

J. Chem. Eng. Data

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Densities of aqueous solutions of the chiral (racemic, with the enantiomer ratio of 1:1) 2-monomethylglycoluril (MMGU) and 2,4,6-trimethylglycoluril (TriMGU) have been measured using an Anton Paar DMA 5000 M densimeter. All density experiments have been performed with a precision of 0.025 kg•m −3 in the temperature range between 278.15 and 318.15 K (with a step of 10 K) at a pressure of (99.6 ± 0.08) kPa. The solute molality is in the range from 0.032 to 0.523 mol•(kg H 2 O) −1 , respectively. The temperature-dependent standard (apparent at infinite dilution) molar volumes and expansibilities of MMGU and TriMGU in water have been derived from the density data. The molar volumetric characteristics for MMGU or TriMGU as a solute in the aqueous medium have been discussed within the scope of comparative analysis including the previously obtained similar quantities for the chiral 2,6-dimethyglycoluril (trans-DMGU).

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Section: Introductionmentioning

confidence: 99%

Standard Volumetric Properties of Chiral N-Methyl-Substituted Glycolurils in Water between 278.15 and 318.15 K at Ambient Pressure

Ivanov

2018

J. Chem. Eng. Data

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“…The quantitative determination of N-alkylated glycoluril derivatives can be carried out using the Kjeldahl method [104]. To quantitatively determine the N,N,N,N-tetramethylglycoluril, the methods of cerimetric and iodometric titration can also be used [105].…”

Section: Chemical Methods Of Analysismentioning

confidence: 99%

“…Several examples of the gas chromatographic analysis of glycoluril derivatives are known. For instance, it was proposed to separate fully alkylated glycoluril derivatives: N,N,N,N-tetramethylglycoluril, N,N,N,Ntetraethylglycoluril, N,N,N,N-dimethyldiethylglycoluril, and N,N,N,N-isopropyltrimethylglycoluril using a one-meter-long packed chromatographic column filled with stationary phase G3 OV-17 (50 % diphenyl-, 50 % dimethylpolysiloxane) [104].…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Methods of analysis of glycoluril and its derivatives

Бакибаев¹,

Ras²,

Malkov³

et al. 2020

Bull. of the Kar. Univ. "Chem". Ser.

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The present work provides the literature data generalization concerning analysis of glycoluril, its derivatives and related compounds that allows obtaining information about the structure and properties of these com-pounds. Basic methods for analysis of glycoluril and substances on the basis thereof are considered, ad-vantages and disadvantages of these methods are described. The generalized results of the methods of analy-sis of glycoluril and its derivatives show that the majority of carried studies are focused on the revealing of purity and identification of related impurities for compounds that found practical application (drugs, mono-mers and polymers on the basis thereof). Consistent trend to active search of new methods to analyze macrocyclic and supramolecular systems synthesized on the basis of glycoluril is observed. The aim of the present review is to take attention of chemists to the most advanced methods of analysis of glycoluril and its derivatives with reference to promotion of further research. The literature analysis will be useful for research-ers dealing with designing of new molecules based on glycoluril with given properties where the methods of process control and analysis of target compounds has a decisive importance.

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“…Glycolurils, tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-diones, are wellknown imidazole derivatives of great research interest. As well as serving as building blocks in the preparation of many organic compounds and supramolecular synthons (Burnett et al, 2003;Kravchenko et al, 2018), they have also been reported to behave as nootropic (Ryzhkina et al, 2013), neurotropic (Berlyand et al, 2013) and anxiolytic agents (Kravchenko et al, 2018). Some derivatives are used as flameresistant materials (Sal'keeva et al, 2016;Zharkov et al, 2015) and gelators (Tiefenbacher et al, 2011).…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of a new dithioglycoluril: 1,4-bis(4-methoxyphenyl)-3a-methyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dithione

et al. 2019

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In the title dithioglycoluril derivative, C19H20N4O3S2, there is a difference in the torsion angles between the thioimidazole moiety and the methoxyphenyl groups on either side of the molecule [C—N—Car—Car = 116.9 (2) and −86.1 (3)°, respectively]. The N—C—N bond angle on one side of the dithioglycoluril moiety is slightly smaller compared to that on the opposite side, [110.9 (2)° cf. 112.0 (2)°], probably as a result of the steric effect of the methyl group. In the crystal, N—H...S hydrogen bonds link adjacent molecules to form chains propagating along the c-axis direction. The chains are linked by C—H...S hydrogen bonds, forming layers parallel to the bc plane. The layers are then linked by C—H...π interactions, leading to the formation of a three-dimensional supramolecular network. Hirshfeld surface analysis and two-dimensional fingerprint plots were used to investigate the molecular interactions in the crystal.

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Chemico-Pharmaceutical Analysis of the Biologically Active Substances Albicar

Cited by 17 publications

References 0 publications

Standard Volumetric Properties of Chiral N-Methyl-Substituted Glycolurils in Water between 278.15 and 318.15 K at Ambient Pressure

Standard Volumetric Properties of Chiral N-Methyl-Substituted Glycolurils in Water between 278.15 and 318.15 K at Ambient Pressure

Methods of analysis of glycoluril and its derivatives

Crystal structure and Hirshfeld surface analysis of a new dithioglycoluril: 1,4-bis(4-methoxyphenyl)-3a-methyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dithione

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