Chemically Tunable Lensing of Stimuli‐Responsive Hydrogel Microdomes

Ehrick, Jason D.; Stokes, Sean M.; Bachas-Daunert, Stephanie; Moschou, Elizabeth A.; Deo, Sapna K.; Bachas, Leonidas G.; Daunert, Sylvia

doi:10.1002/adma.200601969

Cited by 49 publications

(36 citation statements)

References 21 publications

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“…For example, Daunert and co-workers designed acrylamide-based hydrogel containing genetically engineered protein – calmodulin (CaM) (93, 94). The molecular recognition between CaM and calcium ions triggers the conformational change of CaM and its binding to phenothiazine (both CaM and phenothiazine were polymer-conjugated).…”

Section: Peg Hydrogels In Emerging Regenerative Medicinementioning

confidence: 99%

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

2008

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Section: Peg Hydrogels In Emerging Regenerative Medicinementioning

confidence: 99%

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

2008

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“…The increases in hydrogel swelling were reversible upon removal of the chlorpromazine or EGTA molecules. In a similar approach, Daunert and coworkers [36] have recently synthesized dynamic poly(acrylamide) hydrogel microlens arrays based on CaM-phenothiazine crosslinks. The optical properties of the hydrogel lenses were chemically tunable using soluble chlorpromazine.…”

Section: Dynamic Hydrogels Based On Competitive Interactionsmentioning

confidence: 97%

Bioinspired Design of Dynamic Materials

2009

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An emerging approach for design of dynamic materials involves mimicking natural systems, which are adept at changing their structure and function in response to their environment. Biological systems possess a diverse range of dynamic mechanisms, including competitive ligand–protein binding, enzyme‐catalyzed remodeling, and allosteric protein conformational changes. These dynamic mechanisms are now being exploited by materials scientists and engineers to design “bioinspired” synthetic materials that undergo responsive assembly and disassembly as well as dynamic volume and shape changes. The purpose of this review is to describe recent progress in design and development of bioinspired dynamic materials, with a particular emphasis on hydrogel networks. We specifically focus on emerging approaches that use biological phenomena as an inspiration for design of materials.

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“…206 The binding action of CaM can also be used to modulate physical crosslink density in gels by tethering the CaM as a side group rather than incorporating it into the polymer main chain enabling responsive swelling or deswelling of the gels to create microfluidic actuators 207 and switchable lenses. 18 Finally, the dimerization of gyrase subunit B in the presence of coumermycin has been demonstrated as a method for responsive crosslinking and drug release. 208 Antigen-antibody interactions provide one of the most attractive methods of implementing responsive crosslinking in materials owing to the wide range of antibody-antigen pairs and their extremely high specificity.…”

Section: Hydrogels With Biological Recognition Propertiesmentioning

confidence: 99%

“…[15][16][17] In addition, stimuli-responsive protein gels have been explored as ligand-triggered actuators for micro-optics, biosensors, and controlled release vehicles for drug delivery. 4,[18][19][20] Protein-based hydrogels are easily prepared through four broad synthetic strategies: (a) processing of natural proteins, (b) solid-phase peptide synthesis, 21,22 (c) biological protein expression, 23,24 and (d) N-carboxyanhydride (NCA) polypeptide synthesis. [25][26][27] As the processing of natural proteins does not enable control over protein sequence, synthetic methods such as solid-phase peptide synthesis and biological protein expression have been developed to design materials with precise sequence control, polydispersity index of 1.0, and the ability to incorporate noncanonical amino acids into the material.…”

mentioning

confidence: 99%

Physics of engineered protein hydrogels

Kim

Tang

Olsen

2013

J Polym Sci B Polym Phys

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Artificially engineered proteins and synthetic polypeptides have attracted widespread interest as building blocks for polymer hydrogels. The biophysical properties of the proteins, such as molecular recognition abilities, folded chain structures, and sequence-dependent thermodynamic behavior, enable advances in functional, responsive, and tunable gels. This review discusses the design of polymer hydrogels that incorporate protein domains, highlighting new challenges in polymer physics that are presented by this emerging class of materials. Five types of engineered protein hydrogels are discussed: (a) physically associating protein polymer gels, (b) amorphous artificially engineered protein networks, (c) engineered proteins with crystalline domains, (d) stretchable protein tertiary structures in gels, and (e) protein gels with biological recognition properties. The physics of the protein component and the physical properties of the resulting hydrogels are summarized, illustrating how advances in understanding these systems are leading to exciting novel biofunctional hydrogels.

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Chemically Tunable Lensing of Stimuli‐Responsive Hydrogel Microdomes

Cited by 49 publications

References 21 publications

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

Bioinspired Design of Dynamic Materials

Physics of engineered protein hydrogels

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