Chemically Stable Films for Combinatorial Fluorosensor Arrays

Abstract

Sensor arrays are useful for many purposes. Our interests include quasi-distributed intrinsic fiber optic arrays, those distributed along the length of an optical fiber. We have demonstrated an optical time-of-flight approach to distinguishing the fluorescence output of such arrays, as well as a synthesis of combinatorial libraries that takes advantage of a support of linear morphology to make numerous compounds in a simple manner without information loss in the synthesis. To unite these research areas, we needed an optical fiber cladding material that meets demanding synthetic and optical requirements. We have chosen the Meldal SPOCC polymer support as the best candidate for such a material and report here our initial results with this material.

Organic Polymer Supports for Synthesis and for Reagent and Catalyst Immobilization

“…These resins all exhibit good mechanical properties and excellent swelling in polar solvents. When tetraethylene glycol is used as the PEG starting material, the resulting SPOCC-194 resin has a high loading capacity of 0.9−1.2 mmol g −1 that can be used in a variety of solid-phase synthesis applications and, interestingly, even as a functionalizable optical fiber cladding material …”

“…When tetraethylene glycol is used as the PEG starting material, the resulting SPOCC-194 resin has a high loading capacity of 0.9-1.2 mmol g -1 that can be used in a variety of solid-phase synthesis applications 175 and, interestingly, even as a functionalizable optical fiber cladding material. 176 Similarly, Albericio has described the use of ChemMatrix resin (Figure 15) that is cross-linked by PEG as a support for solid-phase peptide synthesis. 177 This polymer is notable in that it only contains primary ether bonds and is therefore highly chemically stable.…”