Chemically modified resins for solid-phase extraction

Sun, Jeffrey J.; Fritz, James S.

doi:10.1016/0021-9673(92)85382-4

Cited by 99 publications

(27 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Normal-phase, reversed-phase, ionexchange and even immunoaffinity methods are now common approaches for SPE protocols. Recently, pairing independent (orthogonal) modes of retention on the same solid-phase support has attracted the attention of the analytical chemist which allowed higher selectivity for certain analytes (Thompson et al , 1990;Sun and Fritz, 1992). However, none of these methods increases the inherent sensitivity to detection.…”

Section: Introductionmentioning

confidence: 98%

Automated HPLC analyses of drugs of abuse via direct injection of biological fluids followed by simultaneous solid‐phase extraction and derivatization with fluorescence detection

Bourque

Krull

Feibush³

1994

Biomedical Chromatography

View full text Add to dashboard Cite

An automated system is described for the simultaneous extraction and derivatization of nucleophilic compounds from various biological media. The method includes the use of a solid-phase reagent containing a 9-fluorenylacetate activated ester. The reagent is based on a controlled pore, polystyrene divinylbenzene support prepared through a silica template procedure. An X-Y-Z robotic arm equipped with a needle is used in conjunction with a syringe pump for aspirating and dispensing samples and standards into the HPLC system. A precolumn cartridge containing the solid-phase reagent is put on-line in place of the fixed-volume injection loop. Injections of biological fluids such as urine or plasma with minimal sample treatment and handling are made directly into this reactor. The analytes are derivatized as they are extracted, allowing virtually unlimited sample volumes to be injected. The polymeric cartridge can be used for up to 100 injections without accruing unacceptable reductions in sensitivity. A detection limit of 500 p.p.t. (parts per trillion) of amphetamine in urine was achieved with this system.

show abstract

Section: Introductionmentioning

confidence: 98%

Automated HPLC analyses of drugs of abuse via direct injection of biological fluids followed by simultaneous solid‐phase extraction and derivatization with fluorescence detection

Bourque

Krull

Feibush³

1994

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Different polar functional groups such as acetyl [5, 12 -15], hydroxymethyl [13,14], benzoyl [6], and o-carboxybenzoyl [16 -18] have been introduced into polymeric resins. There are also some commercially available functionalized PS-DVB such as Bond Elut PPL [7,17].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Polymeric Sorbents for Solid-Phase Extraction of Polar Pollutants

Masqué

Galià

Marcé

et al. 1999

J. High Resol. Chromatogr.

View full text Add to dashboard Cite

This study assesses how the physical characteristics of styrene‐divinylbenzene (PS‐DVB) resins affect the extent to which they are modified when they are functionalized, and how they affect recoveries in on‐line solid‐phase extraction (SPE) of some polar phenolic compounds, pesticides, and metabolites from water samples which were analyzed by liquid chromatography and UV detection. For this purpose, three commercial PS‐DVB resins with different physical characteristics (Amberchrom GC‐161m and two different PLRP‐S resins) were chemically modified by placing a hydrophilic group, an o‐carboxybenzoyl moiety, on their surface; although the physical characteristics are different, the extent of modification did not vary significantly. The results from the SPE process with each sorbent were related to their physical and chemical properties. The polymers with higher surface area provided better recoveries. Moreover, the recoveries for these analytes were better with the chemically‐modified polymers due to the higher polarity of these sorbents. The best recovery values were with the sorbent obtained from the chemical modification of Amberchrom GC‐161m, the commercial sorbent with higher surface area. For instance, in the analysis of 50 mL of a sample of 2 μg L–1, the recovery of phenol was 40% with Amberchrom GC‐161m and 65% with the chemically‐modified Amberchrom GC‐161m.

show abstract

“…Sun and Fritz found that extraction with polymeric resins resulted in higher recovery for many types of analytes [9,6]. Both silica and polymeric stationary phases have some disadvantages [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Commercial Solid-Phase Extraction (SPE) Carrier Materials for the Selective Automated Enrichment of Monoterpenoides and their Analysis in Cough Drops, Mouthwashes and Bath Additives by Gas- Chromatography Mass Spectrometry (GC-MS)

Uhlschmied

Krieg²,

Abel³

et al. 2013

TOACJ

View full text Add to dashboard Cite

For sample preparation solid-phase extraction (SPE) became very popular during the 1980s and 1990s. Because method development and its optimization is very time consuming, in most cases C 18 is used as standard carrier material without knowing if it possesses the highest efficiency. Therefore detailed studies with different stationary phases are necessary for optimal recovery rates. Due to the resulting high number of samples, automation is of crucial importance. In the study described, the extraction of five monoterpenoids (myrcene, citronellal, p-cymene, menthol and thymol) out of an ethanolic solution was optimized using automated SPE. An automated robotic system, the MEA Personal Purification System ® from PhyNexus™ Inc.

show abstract

Chemically modified resins for solid-phase extraction

Cited by 99 publications

References 16 publications

Automated HPLC analyses of drugs of abuse via direct injection of biological fluids followed by simultaneous solid‐phase extraction and derivatization with fluorescence detection

Automated HPLC analyses of drugs of abuse via direct injection of biological fluids followed by simultaneous solid‐phase extraction and derivatization with fluorescence detection

Functionalized Polymeric Sorbents for Solid-Phase Extraction of Polar Pollutants

Evaluation of Commercial Solid-Phase Extraction (SPE) Carrier Materials for the Selective Automated Enrichment of Monoterpenoides and their Analysis in Cough Drops, Mouthwashes and Bath Additives by Gas- Chromatography Mass Spectrometry (GC-MS)

Contact Info

Product

Resources

About