Chemically Induced Sperm Retention Cysts in the Rat

Cooper, E. R. A.; Jackson, H.

doi:10.1530/jrf.0.0340445

Cited by 27 publications

(16 citation statements)

References 7 publications

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“…The dilation appears to induce an inflammatory response and sperm granuloma. This sequence of events causes the rete testis to become swollen with seminiferous tubular fluids, and if the distal occlusions are not resolved, the swelling continues into the seminiferous tubules, leading to back-pressure atrophy of the testis (Cooper and Jackson, 1972;Cooper and Jackson, 1973). These same sequelae are seen with other chemicals, including ethylenedimethane sulfonate (Cooper and Jackson, 1972) and the fungicides benomyl and carbendazim (Nakai et aI, 1992;Nakai et aI, 1993;Hess and Nakai, 2000).…”

Section: Experimental Factorsmentioning

confidence: 98%

“…This pattern of pathological response is repeated in cases of ablation of the epididymal blood vessels in the rat (MacMillan, 1953) and in vasectomized rhesus monkeys (Tung and Alexander, 1980). Sperm blockage in the efferent ductules, which results in testicular swelling, has been found to occur immediately following administration of a-chlorohydrin (Ericsson, 1970;Cooper and Jackson, 1972;Cooper and Jackson, 1973;Hoffer et aI, 1973). Regardless of the biochemical mechanisms of a-chlorohydrin-induced pathology, the morphological response of the rete testis and the efferent ductules is similar to that found after ligation.…”

Section: Experimental Factorsmentioning

confidence: 99%

See 1 more Smart Citation

The Efferent Ductules: Structure and Functions

Hess

2002

The Epididymis: From Molecules to Clinical Practice

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Section: Experimental Factorsmentioning

confidence: 98%

Section: Experimental Factorsmentioning

confidence: 99%

The Efferent Ductules: Structure and Functions

Hess

2002

The Epididymis: From Molecules to Clinical Practice

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“…The most popular belief is that there is a rupture of the epididymal tubule resulting from increased intraluminal pressure, and eruption of the sperm from the break into the interstitium followed by a responsive inflammation which forms a nodule encapsulating the sperm. 76 However, it is also plausible to consider that inflammatory changes can be driven by an imbalance in the dynamic equilibrium between immune tolerance and toxicant mediated 'activation' of inflammation in the epididymis (also see Gregory and Cyr, this issue). Methyl chloride is an example of a well known chemical provoking sperm granulomas.…”

Section: Inflammatory Infiltratesmentioning

confidence: 99%

Interpreting histopathology in the epididymis

Kempinas

Klinefelter

2014

Spermatogenesis

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“…Obstructive lesions in the head of the epididymis have also been associated with the process of recanalization (Cooper and Jackson, 1973;Ball and Mitchinson, 1984;Hess et al, 1991;Nakai et al, 1992). However, these reports of terminal lesions have provided little under-standing of cytological responses that lead to epithelialization of injured efferent ductules.…”

Section: Occlusion Carbendazim Ratmentioning

confidence: 99%

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

1993

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Occlusions of the rat efferent ductules were induced by an oral gavage of carbendazim and the capacity for regeneration or recanalization of the ductules was histologically evaluated between 2 and 70 days post-treatment. At 2 days post-treatment, the efferent ductules were occluded by sloughed materials and showed various degrees of inflammation. Severely damaged epithelium showed few regenerative features at later intervals. On the other hand, epithelia with medium inflammation often exhibited irregular epithelial growth along the luminal contents or the formation of multiple abnormal ductules. These abnormal ductules were formed by migrated and original epithelia at the periphery of the occluded lumen at 16 days post-treatment, indicating attempted recanalization. At later time periods, 32 and 70 days post-treatment, the occluded original lumen was filled in by fibrotic connective tissue and surrounded by a series of abnormal ductules. These abnormal ductules were characterized by cuboidal epithelia, a small luminal diameter, fewer cilitated cells than normal, less developed organelles in the epithelial cells, and basal laminae of irregular thickness. However, there was no evidence that occluded ductules formed patent re-connections via abnormal ductules. The results suggest that occluded efferent ductules have the ability to initiate epithelial regrowth and to form new ductules, but the newly formed ductules are abnormal and are not adequate to recover from azoospermia at least at 70 days post-treatment.

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Chemically Induced Sperm Retention Cysts in the Rat

Abstract: Summary. The

Cited by 27 publications

References 7 publications

The Efferent Ductules: Structure and Functions

The Efferent Ductules: Structure and Functions

Interpreting histopathology in the epididymis

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

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