Chemical vs thermal accelerated hydrolytic degradation of 3D-printed PLLA/PLCL bioresorbable stents: Characterization and influence of sterilization

Chausse, Víctor; Iglesias, Clàudia; Bou‐Petit, Elisabeth; Ginebra, Maria‐Pau; Pegueroles, Marta

doi:10.1016/j.polymertesting.2022.107817

Cited by 16 publications

(24 citation statements)

References 43 publications

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“…Data were firstly obtained from PLLA degradation tests at 50 °C in PBS 1X solution, an approach usually performed to accelerate the polymer degradation (specifically for those degrading in more than 3 years) since testing for such a long period would be time-consuming. It is worth highlighting that elevated temperature may alter the degradation mechanism, making the data obtained at elevated temperature irrelevant to degradation at 37 °C [ 24 ]. However, this phenomenon was investigated by Weir et al [ 27 ], who carried out degradation experiments on PLLA samples at 37 °C, 50 °C, and 70 °C, concluding that degradation proceeds in a similar way at the elevated temperatures to that observed at 37 °C in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…The in vitro degradation of PLLA was assessed via gel permeation chromatography (GPC) of rod samples (n = 3; dimensions of 1.6 mm in diameter and 6 mm height) at 50 °C in phosphate-buffered saline (PBS) 1X (phosphate-buffered saline, Sigma-Aldrich) for 2 months. Degradation tests on PLLA pellets were performed at 50 °C to accelerate the polymer degradation due to the increase in chain and mobility [ 22 , 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…According to the literature, the Arrhenius relation can be applied to determine the model parameters (e.g.,

) at different temperatures [ 23 , 24 ]. The Arrhenius relation comprises two constants: the activation energy,

, and a pre-exponential factor,

[ 25 ].…”

Section: Methodsmentioning

confidence: 99%

“…The activation energies for each parameter were taken from the literature [ 24 ], whereas the pre-exponential factors were computed with the Arrhenius equation using the parameters validated at 37 °C for the degradation of PLA plates, and the respective activation energies [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

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A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

et al. 2023

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This work presents a computational model to study the degradation behavior of polyester-based three-dimensional (3D) functionalized scaffolds for bone regeneration. As a case study, we investigated the behavior of a 3D-printed scaffold presenting a functionalized surface with ICOS-Fc, a bioactive protein able to stimulate bone regeneration and healing, inhibiting osteoclast activity. The aim of the model was to optimize the scaffold design to control its degradation and thus the release of grafted protein over time and space. Two different scenarios were considered: (i) a scaffold without macroporosity presenting a functionalized external surface; and (ii) a scaffold presenting an internal functionalized macroporous architecture with open channels to locally deliver the degradation products.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…According to the literature, the Arrhenius relation can be applied to determine the model parameters (e.g.,

) at different temperatures [ 23 , 24 ]. The Arrhenius relation comprises two constants: the activation energy,

, and a pre-exponential factor,

[ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

et al. 2023

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“…[4] In order to improve the sterilization capacity, the use of γ-rays to irradiate medical supplies is getting more and more attention. [5] During the sterilization process of medical disposable protective clothing by γ irradiation, the changes in molecular structure caused by the irradiation can result in free radical-induced after-effects, [6][7][8] which lead to material property deterioration and cannot meet the usage requirements. [9] The main material of medical disposable protective clothing is polypropylene, [10] its radiation mainly involves β degradation.…”

Section: Introductionmentioning

confidence: 99%

The Structure and Properties of Medical Disposable Protective Clothing Materials with Different Packaging and Models under γ Irradiation

Tian,

Li,

et al. 2024

ChemistrySelect

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This study investigated the radiation effects of commercially available medical disposable protective clothing materials under γ irradiation. FT‐IR, contact angle, DSC, OIT, and mechanical properties were used to examine the radiation effects of medical disposable protective clothing materials. The results showed when the radiation dose was less than or equal to 50 kGy, the FT‐IR spectra did not show any changes. However, when the radiation dose reached 70 kGy, new absorption peaks appeared in the infrared spectra of the TS−A and TS−B medical disposable protective clothing materials, indicating chemical changes. Contact angle analysis showed that medical disposable protective clothing materials were hydrophobic and had higher hydrophobicity on the inside than the outside under different packaging and irradiation conditions. Rheological analysis showed that the shear thinning phenomenon of medical disposable protective clothing materials increased significantly with the increase of radiation dose, and good rheological behavior was observed under vacuum packaging conditions when the radiation dose was 30 kGy. The crystallinity and initial crystallization temperature showed the order of vacuum, nitrogen, and air. The oxidation induction time trend was vacuum>nitrogen>air, while the fracture strength trend was nitrogen>vacuum>air. The mechanical properties met the national standard.

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3D‐Printed Shape Memory Poly(alkylene terephthalate) Scaffolds as Cardiovascular Stents Revealing Enhanced Endothelialization

Van Daele,

Chausse,

Parmentier

et al. 2024

Adv Healthcare Materials

Self Cite

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Cardiovascular diseases are the leading cause of death and current treatments such as stents still suffer from disadvantages. Balloon expansion causes damage to the arterial wall and limited and delayed endothelialization gives rise to restenosis and thrombosis. New more performing materials that circumvent these disadvantages are required to improve the success rate of interventions. To this end, we investigated the use of a novel polymer, poly(hexamethylene terephthalate), for this application. We optimized the synthesis to obtain polymers with high molar masses up to 126.5 kg/mol and performed a thorough chemical and thermal analysis. We 3D‐printed the polymers into personalized cardiovascular stents using the state‐of‐the‐art solvent‐cast direct‐writing technique, established the potential of these stents to expand using their shape memory behavior and showed that the stents are more resistant to compression than the PLLA benchmark. Furthermore, we demonstrated the polymer's hydrolytic stability in an accelerated degradation study of six months. Finally, the stents were subjected to an in vitro biological evaluation, revealing that the polymer is non‐hemolytic and supports significant endothelialization after only 7 days, demonstrating the enormous potential of these polymers to serve cardiovascular applications.This article is protected by copyright. All rights reserved

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Chemical vs thermal accelerated hydrolytic degradation of 3D-printed PLLA/PLCL bioresorbable stents: Characterization and influence of sterilization

Cited by 16 publications

References 43 publications

A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

The Structure and Properties of Medical Disposable Protective Clothing Materials with Different Packaging and Models under γ Irradiation

3D‐Printed Shape Memory Poly(alkylene terephthalate) Scaffolds as Cardiovascular Stents Revealing Enhanced Endothelialization

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