Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases

Christianson, David W.

doi:10.1021/acs.accounts.3c00801

Acc. Chem. Res.

2024

DOI: 10.1021/acs.accounts.3c00801

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Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases

David W. Christianson

Abstract: This paper shows how intact enzyme− substrate complexes can be stabilized through mutagenesis, crystallized, and studied by X-ray crystallography.

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Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases

Abstract: This paper shows how intact enzyme− substrate complexes can be stabilized through mutagenesis, crystallized, and studied by X-ray crystallography.

Cited by 3 publications

References 87 publications

Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design

Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design

Posttranslational modifications of E2F family members in the physiological state and in cancer: Roles, mechanisms and therapeutic targets

Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

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